CLUSTAL 2.1 multiple sequence alignment


Human           ------------------------------------------------------------
Cow             ------------------------------------------------------------
Mouse           ------------------------------------------------------------
Rat             ------------------------------------------------------------
Dog             MVNSERRDSQPLAWYAAQTGDLRVPAWEECRSRALPSTPACASVSALGAQGNSASSRWRP 60
Chicken         ------------------------------------------------------------
Zebrafish       ------------------------------------------------------------
Nematode        ------------------------------------------------------------
                                                                            

Human           ------------------------------------------------------------
Cow             ------------------------------------------------------------
Mouse           ------------------------------------------------------------
Rat             ------------------------------------------------------------
Dog             LLGRALSLPEQHAGLNMNSIRGMQPVLSEDGGVPPAIAYLIFNVLNKPVLLILYLPELRP 120
Chicken         ------------------------------------------------------------
Zebrafish       ------------------------------------------------------------
Nematode        ------------------------------------------------------------
                                                                            

Human           ------------------------------------------------------------
Cow             ------------------------------------------------------------
Mouse           ------------------------------------------------------------
Rat             ------------------------------------------------------------
Dog             LMALLLLEVRSAGMGTLTRGSPGIRPPKPRPPAACAVAVSLLPGSSEPTDRPGLMISVCG 180
Chicken         ------------------------------------------------------------
Zebrafish       ------------------------------------------------------------
Nematode        ------------------------------------------------------------
                                                                            

Human           MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGP-------AGGALYAP 53
Cow             MAAATSPPRAERKRWGGGRLPGARRGSAGLAKKCPFSLELAEGSP-------AGSALYAP 53
Mouse           MDTASSPPSAERKRAGWSRLLGARRG-SAVVKKCPFSLELAEGGP-------EGSTVYAP 52
Rat             MDTASSPPNAERKRAGWGRLLGARRGSAGLAKKCPFSLELAEGGP-------TGGTVYAP 53
Dog             EKDGEDPGARSEDRLHLSTVRGVLSRCTFPAASIWTGEKLLEGVT-------VGAETGVH 233
Chicken         ---MSSSSPPGEHRSRSLGRLSLPRKGSMTPGKKPSSLELAESVPNAHYAPLPEAQGGQP 57
Zebrafish       ---MTSPAHSTATEASWTAGAADLQMTEALHLRN-------------------------- 31
Nematode        -----------------------------------------------------MLTTSGY 7
                                                                            

Human           IAPGAPGPAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVY-- 111
Cow             IAPPG-----APGPVSPAAPPAAADLGPRPRVSLDPRVSIYSARRPLLARTHIQGRVY-- 106
Mouse           IAPTGAPGLAPPMSTPVSPAPAPADLGPRPRVSLDPRVSIYSARRPLLARTHIQGRVY-- 110
Rat             IAPTGAPGLAPPMSPPVSPVPAPADLGPRPRVSLDPRVSIYSTRRPLLARTHIQGRVY-- 111
Dog             PDATATTTSKLGPAVPWEAECGVQNLDLRRVEGLERCEPPSSRMSSKRSACWFSSLLG-- 291
Chicken         PAGSGPGAARERPPHVRSEVVVVGAESARPPVSLDPRVSIYSLRKPLLSRSNIQGRVYNF 117
Zebrafish       ----------DGVRFPSSVPVDPAVITQHPPSHLHPRMSVYSATRPTLSRSFLQGRVYN- 80
Nematode        PNGSLRSSLDDSPQDPEESETFLLGMVTGDGLGKMFNARYRNIKEKKAAKMTYRAMIYN- 66
                                                         .      :     . :   

Human           ---NFLER-----------------------------------PTGWKCFVYHFAVFLIV 133
Cow             ---NFLER-----------------------------------PTGWKCFVYHFAVFLIV 128
Mouse           ---NFLER-----------------------------------PTGWKCFVYHFTVFLIV 132
Rat             ---NFLER-----------------------------------PTGWKCFVYHFTVFLIV 133
Dog             ---VQVHTPQCDLGTGGRDSGASDTNEPCVPPIHLLETKGGLAPPAGGFVQLAGFSFLIV 348
Chicken         LER----------------------------------------PTGWKCFVYHFTVFLIV 137
Zebrafish       ----FLER-----------------------------------PTGWKCFVYHFTVFLIV 101
Nematode        ----CLER-----------------------------------PTGWKCFLYHFSVFLIV 87
                                                           *..   .      ****

Human           LVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRF 193
Cow             LVCLIFSVLSTIEQYVALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRF 188
Mouse           LVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRF 192
Rat             LVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRF 193
Dog             LVCLIFSVLSTIEQYVALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRF 408
Chicken         LICLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRF 197
Zebrafish       LSCLILSVLSTIDEYQALANKTLFWMELVLVMFFGVEYVVRLWSAGCRSKYVGILGRLRF 161
Nematode        LICLILSVLSTVEEHSHFAAELLYILEIVLVVFFSVEFIVRLWSAGCRSKYIGVYGRLKF 147
                * ***:*****::::  :*   *: :*:***:**..*::************:*: ***:*

Human           ARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGS 253
Cow             ARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGS 248
Mouse           ARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGS 252
Rat             ARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGS 253
Dog             ARKPISIIDLIVVLASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGS 468
Chicken         ARKPISIIDLIVVVASMIVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGS 257
Zebrafish       ARKPISVIDLIVVVASIIVLAFGSNGQVFATSAVRGVRFLQILRMLHVDRQGGTWRLLGS 221
Nematode        VRKPITLIDLVVVICSLFVICFGTEGQVFAASAMRGIRFLQILRMLHVDRQGGTWRLLGS 207
                .****::***:**:.*:.*:..*::*****:**:**:***********************

Human           VVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTI 313
Cow             VVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGQVEFGSYADALWWGVVTVTTI 308
Mouse           VVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRIEFGSYADALWWGVVTVTTI 312
Rat             VVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRIEFGSYADALWWGVVTVTTI 313
Dog             VVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNDSGQVEFGSYADALWWGVVTVTTI 528
Chicken         VVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNDSGETEFGSYADALWWGVVTVTTI 317
Zebrafish       VVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVDDHGNSGFGSYADALWWGVVTVTTI 281
Nematode        VVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDHIGVDGRQAFTSYADALWWGVITMTTI 267
                ********************************* :.  *.  * **********:*:***

Human           GYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAAS 373
Cow             GYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAAS 368
Mouse           GYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAAS 372
Rat             GYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAAS 373
Dog             GYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAAS 588
Chicken         GYGDKVPQTWIGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAAS 377
Zebrafish       GYGDKVPQTWIGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAAS 341
Nematode        GYGDVVPQTWLGRIVASCFSIFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAAT 327
                **** *****:*: :*****:**************************************:

Human           LIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKDNGVTP 433
Cow             LIQTAWRCYAAENPDSSTWKIYVRKPSRNHALLSPSPKPKKSAMVKKKKFKLDKDNGVSP 428
Mouse           LIQTAWRCYAAENPDSATWKIYVRKPARSHTLLSPSPKPKKSVMVKKKKFKLDKDNGMSP 432
Rat             LIQTAWRCYAAENPDSSTWKIYVRKPARSHTLLSPSPKPKKSVMVKKKKFKLDKDNGLSP 433
Dog             LIQTAWRCYAAENPDSSTWKIYVRKPARSHALLSPSPKPKKSVMVKRKKFKQDKDNGVSP 648
Chicken         LIQTAWRCYAAENPDSSTWKIYIRRPARNYHLLSPSPKPKKSVMVKKKKFKLDKDNGPSS 437
Zebrafish       LIQASWRCFALLNPDSATYKLFVKRN-----LSSSGSSPKLKVKMRRKMKISDRNNGQNS 396
Nematode        LIQCLWRCHAAEKKVSATWNAHIDPLAHETKETHHWNGKKHASSMDSNNLTRKRQLFKKQ 387
                ***  ***.*  :  *:*:: .:                *    :  :    .::   . 

Human           GEKMLTVPHITCDPPEE-RRLDHFSVDGYDSSVR-------------------------- 466
Cow             GEKALVVPHITCDPVAEDRRPEPFSVDGYDSTVK-------------------------- 462
Mouse           GEKMFNVPHITYDPPED-RRPDHFSIDGYDSSVR-------------------------- 465
Rat             GEKIFNVPHITCDPPED-RRPDHFSIDGYDSSVR-------------------------- 466
Dog             GEKMLTVPHITCEPVSEERRPDHFSVDNCDSSVK-------------------------- 682
Chicken         PDKMLTVPHITYDHVTD-DKKPDFCFDTYENSVK-------------------------- 470
Zebrafish       P----AVPSITYDSFDDGRDSRQETLTSLQQSVISDGTNTTRRYERAPSWNSLSSFQFST 452
Nematode        SSLVNTFRRKGSPSTDVEMGELQQERLLRHERNS-------------------------- 421
                      .                      ..                             

Human           ----KSPTLLEVSMPHFMRTNSFAEDLDLEG--ETLLTPITHISQLREHHRATIKVIRRM 520
Cow             ----KSPTLLEVSTAHFMRTNSFAEDLDLDG--EALLTPITHVSQLREHHRATIKVIRRM 516
Mouse           ----KSPTLLEVSTPHFLRTNSFAEDLDLEG--ETLLTPITHVSQLRDHHRATIKVIRRM 519
Rat             ----KSPTLLEVSTPHFLRTNSFAEDLDLEG--ETLLTPITHVSQLRDHHRATIKVIRRM 520
Dog             ----KSPMLLEVSTAHFMRTNSFAEDLDLEG--ETLLAPITHVSQLREHHRATIKVIRRM 736
Chicken         ----KSPTFLDVNTGPFIRTNSFADELDLEG--ETLLTPITHISQLREHHRAAIKVIRRM 524
Zebrafish       PPATKPGVFEVSSRPTLQRSSSIADDMETEPEREIVLIPVAHVSQLRDSHRAAIRVIQRM 512
Nematode        ------DTDDEKRIYRVGADIEIDYETEEPTTPTRPQGHISHVCELTDAHRNAIRAIRRV 475
                                .    .:  : :           ::*:.:* : ** :*:.*:*:

Human           QYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKS 580
Cow             QYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKT 576
Mouse           QYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFIPISEKS 579
Rat             QYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFIPISEKS 580
Dog             QYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKS 796
Chicken         QYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKS 584
Zebrafish       YYFVARKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDHSLGKQSLFQTSSERL 572
Nematode        KYFVARRRFQQARKPYDVRDVIEQYSQGHLNMMVRIKELQRRLDQTLGKPGQYDG--KGS 533
                 ****:::***********************:************:::** . :    :  

Human           KDRGSNTIGARLNRVEDKVTQLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQ 640
Cow             KDRGSNSIGARLNRVEDKVTQLDQRLVLITDMLHQLLALQNGGPPAGRPPSTAGAQAVQP 636
Mouse           KDRGSNTIGARLNRVEDKVTQLDQRLVIITDMLHQLLSMQQGG-------PTCNSRSQVV 632
Rat             KDRGSNTIGARLNRVEDKVTQLDQRLVIITDMLHQLLSLQQGG-------PTCNNRSQVV 633
Dog             KDRGSNTIGARLNRVEDKVTQLDQRLVLITDMLHQLLSLYHGGPPG----GRPPSGSGVQ 852
Chicken         KDRGNNTIGARLNRVEDKVTQMDQKLNLITEMLHRLVSSHQRD------------QGNNR 632
Zebrafish       KDKGTNTIGSRLNRMDEKITHMDRTLNSIAESLNLMLARERRG------------DLARG 620
Nematode        RKGHPVTIGSRLSRLELQMSSLDRKVESSNRTLNALYRLMADR-------------NSLT 580
                :.    :**:**.*:: ::: :*: :      *: :                        

Human           PCGSGGSVDPELFLPSNTLPTYEQLTVPRRGPDEGS----- 676
Cow             --SSGGSINPELFLPSNALPTYEQLTVPHGGPDEGS----- 670
Mouse           ASNEGGSINPELFLPSNSLPTYEQLTVPQTGPDEGS----- 668
Rat             ASDERGSINPELFLPSNSLPTYEQLTVPQTGPDEGS----- 669
Dog             VVQPCSSINPELFLPSNTLPTYEQLTVPRRGPEEGS----- 888
Chicken         SSQRGNSVNSDLFIPNNTLPTYEQLTVPERNEDDIS----- 668
Zebrafish       KEQRSTMRRQSATFSLSVLDSSEQLSTTTAIHEDS------ 655
Nematode        ISPSPPALISRPVSPAACLSPRDQLSPTSISSQRSGSPGWQ 621
                              .   * . :**: .    :